By Air: : Madurai Airport, located approximately 174 kilometers from Rameshwaram is the nearest airbase from here. This domestic airport of Madurai provides a very good connectivity with some of the major cities of India such as Bangalore, Delhi, Mumbai, Chennai, Hyderabad, Tirchy, Thiruvananthapuram, Coimbatore, etc. via air. The chief airlines operating at Madurai Airport include Air India, Indian Airlines, Kingfisher Red, Jet Airways, Paramount Airways and Spicejet. Madurai is linked with Rameshwaram via NH 49 which happens to be the shortest route and it takes about 3 and half hours to cover the distance between Madurai and Rameshwaram. Tourists generally prefer to rent a cab which costs nearly 2500 INR for a return trip from Madurai.

By Rail: Rameshwaram is well connected by railway route and it happens to be a major railhead of the ‘Southern Railways’ and a terminus of the meter gauge line. The railway station of Rameshwaram is located at Mandapam about 3 kilometers from the center of the city. Frequent trains plying to and from Rameshwaram connect this holy city with several other important cities of India such as; Bangalore, Madurai, Mysore, Chennai, Coimbatore, Kanyakumari, Hubli, Tiruchirapalli, Thanjavur, Okha, Bhubaneshwar etc. Chief trains running on this route are Rameshwaram Exp, Rameshwaram Chennai Exp, Rameshwaram - Okha Exp, Bangalore Exp, Hubi Exp, Sethu Exp, etc. Annai Indira Gandhi Bridge (popularly known as Pamban Bridge) is an important landmark of Rameshwaram that connects Rameshwaram with the mainland India by rail line as well.

By Road: Rameshwaram is connected to the mainland India by the Pamban Bridge (Annai Indira Gandhi Bridge). Tamil Nadu State Road Transport Service links Rameshwaram with a number of destinations of Tamil Nadu as well as other cities of neighboring states such as Thiruvallur, Kanyakumari, Trichy, Madurai, Thanajvur, Pondicherry, Tanjore, Bangalore, and Chennai etc. Overnight deluxe super fast luxury buses provide connectivity with Bangalore and Chennai from Rameshwaram. Renting a cab is a more comfortable and convenient alternative to reach Rameshwaram by road. NH 49, NH 85 and SH 38 are three major highways that connect Rameshwaram with the extensive road network of India. Rameshwaram is located nearly 168 km from Madurai, 178 km from Thoothukudi, 229 km from Tiruchirappalli, 238 km from Thanjavur, 297 km from Kanyakumari, 401 km from Puducherry, 512 km from Vellore, 535 km from Chennai, 605 km from Bangalore, 1595 km from Mumbai and 2631 km from Delhi.