By Air: Dr. Babasaheb Ambedkar International Airport of Nagpur stationed at the distance of about 75 kilometers from the Pench National Park is the nearest airfield that provides this wildlife sanctuary efficient air connectivity with a number of important domestic and international destinations. More than 6 domestic and 4 international airlines cater their services at the Nagpur International Airport. Air India, GoAir, IndiGo, Jet Airways, JetKonnect, JetLite, Spicejet, etc link Nagpur to a number of metropolitans of India viz. Delhi, Mumbai, Pune, Nanded, Kolkata, Bangalore, Hyderabad, Kochi, Goa, Ahmedabad, Raipur, Indore, Srinagar, etc. via air. Besides, Air Arabia operates a flight to Sharjah (UAE) five times a week while Indian Airlines have started a direct flight to Bangkok which plies twice a week. Silk Air affords connectivity with Singapore, and Qatar Airways is soon to launch Nagpur-Doha biweekly flights. To reach the Pench National Park from the Nagpur Airport tourists can either avail the regularly operating bus services from Ramtek or rent a prepaid cab which will cost around 3,500 to 5,000 INR.

By Rail: The Banapura Railway Station (BPF) of Seoni Malwa located about 62 kilometers from Pench National Park is the nearest railhead that yields an adequate connectivity with New Delhi, Mumbai, Bhopal and Jabalpur by train through the broad gauge rail route. Some of the most noteworthy trains halting at the Banapura Railway Station include; Punjab Mail, Jhelum Exp, Maharashtra Exp, Gorakhpur Exp, Amritsar Exp, Amritsar Dadar Exp, LTT Rajendra Nagar Bihar Exp, Gorakhpur LTT Exp, etc. The Nagpur Railway Station located about 67 kilometers away from Pench is the nearest major train terminal from where 160 trains in total ply every single day.
Some of the most worth mentioning trains commuting from the Nagpur Railway Station are; Mumbai Howrah Mail, Darbhanga- Hyderabad Exp, Vishakapatnam Nizamudin Samata Exp, Bangalore Nizamudin Rajdhani Exp, Bangalore Gorakhpur Exp, Prerana Exp, Sewagram, Nagpur Indore Superfast Exp, Lucknow Exp, Andaman Exp, Kerala Exp, Pune Nagpur Exp, and many others. Nagpur is connected to almost all the important destinations of the country by train, the chief amongst them being; Mumbai, Pune, Ahmedabad, Jaipur, Indore, Jabalpur, Itarsi, Amravati, Lucknow, Amritsar, Kolkata, Delhi, Chandigarh, Jammu, Puri, Dehradun, Hyderabad, Chennai, Ernakulam, Bangalore, Mangalore, Kanyakumari, Coimbatore, Trivandrum, Visakhapatnam, etc.

By Road: National Highway No 7 or the ‘Wardha Road’ passes through the Pench National Park and connects it to Seoni to its north and to Nagpur to its south. Moreover, State Highway No 26 also passes through this Nature Preserve and adjoins it with Seoni and Balaghat. Seoni is the nearest bus junction from Pench from where both Madhya Pradesh and Maharashtra State Transport buses as well as many private buses and cabs are regularly operated. Seoni is very well linked to almost all the towns and cities of Madhya Pradesh and Maharashtra through an extensive road network of state and national highways and also through a proficient network of government operated bus services. Not only that, special buses exclusively bounded to the Pench National Park also ply from Ramtek everyday. It takes just 45 minutes to reach Pench from Ramtek by road. Pench National Park is sited about 35 km from Ramtek, 62 km from Seoni, 67 km from Nagpur, 121 km from Chhindwara, 126 km from Balaghat, 142 km from Wardha, 144 km from Gondia, 208 km from Jabalpur, 209 km from Betul, 220 km from Amravati, etc.